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Mouse Anti-TPRKB Recombinant Antibody (CBYJT-4400) (CBMAB-T3894-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4400
Antibody Isotype
IgG1
Application
WB, FC, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human TPRKB (NP_057142) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPRKB Gene(Protein Coding) TP53RK Binding Protein
Introduction
TPRKB (TP53RK Binding Protein) is a Protein Coding gene. Diseases related to TPRKB include Galloway-Mowat Syndrome 5 and Galloway-Mowat Syndrome. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to TPRKB include protein kinase binding.
Entrez Gene ID
51002
UniProt ID
Q9Y3C4
Alternative Names
TP53RK Binding Protein; PRPK (P53-Related Protein Kinase)-Binding Protein; EKC/KEOPS Complex Subunit TPRKB; TP53RK-Binding Protein; PRPK-Binding Protein; CGI-121; CGI121; GAMOS5
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828).
TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).
Biological Process
Biological Process telomere maintenance via recombination Source:GO_Central1 Publication
Biological Process tRNA threonylcarbamoyladenosine modification Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Nucleus
Involvement in disease
Galloway-Mowat syndrome 5 (GAMOS5):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.
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For research use only. Not intended for any clinical use.

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