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Hamster Anti-TNFRSF9 Recombinant Antibody (CBXC-2450) (CBMAB-C1656-CQ)


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Summary

Host Animal
Hamster
Specificity
Mouse
Clone
CBXC-2450
Antibody Isotype
IgG2
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF9 Gene(Protein Coding) TNF Receptor Superfamily Member 9
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Entrez Gene ID
21942
UniProt ID
P20334
Alternative Names
TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9;
Function
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process regulation of cell population proliferation Source:GO_Central1 Publication
Biological Process regulation of immature T cell proliferation in thymus Source:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 24-186
Helical: 187-213
Cytoplasmic: 214-255
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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