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Mouse Anti-TNFRSF21 Recombinant Antibody (CBYJT-3834) (CBMAB-T3226-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3834
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant human TNFRSF21/DR6 Protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF21 Gene(Protein Coding) TNF Receptor Superfamily Member 21
Introduction
TNFRSF21 is a member of the tumor necrosis factor receptor superfamily. TNFRSF21 activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that TNFRSF21 plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
Entrez Gene ID
27242
UniProt ID
O75509
Alternative Names
TNF Receptor Superfamily Member 21; Death Receptor 6; DR6; Tumor Necrosis Factor Receptor Superfamily, Member 21; Tumor Necrosis Factor Receptor Superfamily Member 21; TNFR-Related Death Receptor 6; CD358 Antigen; BM-018; CD358
Function
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process axonal fasciculation Source:Ensembl
Biological Process B cell apoptotic process Source:UniProtKB
Biological Process cellular response to tumor necrosis factor Source:UniProtKB1 Publication
Biological Process humoral immune response Source:UniProtKB
Biological Process myelination Source:UniProtKB
Biological Process negative regulation of B cell proliferation Source:UniProtKB
Biological Process negative regulation of interleukin-10 production Source:UniProtKB
Biological Process negative regulation of interleukin-13 production Source:UniProtKB
Biological Process negative regulation of interleukin-5 production Source:UniProtKB
Biological Process negative regulation of myelination Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB
Biological Process neuron apoptotic process Source:UniProtKB
Biological Process oligodendrocyte apoptotic process Source:UniProtKB
Biological Process regulation of oligodendrocyte differentiation Source:UniProtKB
Biological Process T cell receptor signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 42-349
Helical: 350-370
Cytoplasmic: 371-655
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For research use only. Not intended for any clinical use.

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