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Mouse Anti-TNFRSF18 Recombinant Antibody (CBFYH-2803) (CBMAB-H0640-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2803
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18, Gln26-Glu161
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF18 Gene(Protein Coding) TNF Receptor Superfamily Member 18
Introduction
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Entrez Gene ID
8784
UniProt ID
Q9Y5U5
Alternative Names
TNF Receptor Superfamily Member 18; Glucocorticoid-Induced TNFR-Related Protein; Activation-Inducible TNFR Family Receptor; AITR; GITR; Tumor Necrosis Factor Receptor Superfamily, Member 18
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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