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Mouse Anti-TNFRSF14 Recombinant Antibody (CBFYC-3170) (CBMAB-C3247-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-3170
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF14 Gene(Protein Coding) TNF Receptor Superfamily Member 14
Introduction
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
8764
UniProt ID
Q92956
Alternative Names
TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
Function
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635).
Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022).
Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304).
Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635).
In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity).
Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050).
May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity).
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).
(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.
(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell surface receptor signaling pathway Source:ProtInc1 Publication
Biological Process defense response to Gram-negative bacterium Source:GO_Central1 Publication
Biological Process defense response to Gram-positive bacterium Source:GO_Central1 Publication
Biological Process immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of adaptive immune memory response Source:UniProtKB1 Publication
Biological Process negative regulation of alpha-beta T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytokine production involved in immune response Source:GO_Central1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of T cell migration Source:GO_Central1 Publication
Biological Process T cell costimulation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 39-202
Helical: 203-223
Cytoplasmic: 224-283
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

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