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Armenian Hamster Anti-TNFR2 Recombinant Antibody (AG181) (V2LY-0524-LY77)


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Summary

Host Animal
Armenian Hamster
Specificity
Mouse
Clone
AG181
Antibody Isotype
IgG
Application
Blocking, IP, WB

Basic Information

Immunogen
Purified Recombinant Mouse TNF R2
Host Species
Armenian Hamster
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tumor necrosis factor receptor superfamily, member 1b
Entrez Gene ID
21938
UniProt ID
P25119
Alternative Names
p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2; Tnfrsf1b
Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
Biological Process
Biological Process agingSource:Ensembl
Biological Process aortic valve developmentSource:BHF-UCL1 Publication
Biological Process cell surface receptor signaling pathwaySource:MGI1 Publication
Biological Process cellular response to growth factor stimulusSource:Ensembl
Biological Process cellular response to lipopolysaccharideSource:MGI
Biological Process extrinsic apoptotic signaling pathwaySource:MGI1 Publication
Biological Process glial cell-neuron signalingSource:ARUK-UCL1 Publication
Biological Process immune responseSource:MGI
Biological Process inflammatory responseSource:MGI1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageSource:MGI1 Publication
Biological Process negative regulation of cardiac muscle hypertrophySource:BHF-UCL1 Publication
Biological Process negative regulation of cell deathSource:ARUK-UCL1 Publication
Biological Process negative regulation of extracellular matrix constituent secretionSource:BHF-UCL1 Publication
Biological Process negative regulation of inflammatory responseSource:MGI1 Publication
Biological Process negative regulation of neuroinflammatory responseSource:ARUK-UCL1 Publication
Biological Process negative regulation of neuron deathSource:ARUK-UCL1 Publication
Biological Process positive regulation of apoptotic process involved in morphogenesisSource:BHF-UCL1 Publication
Biological Process positive regulation of membrane protein ectodomain proteolysisSource:MGI
Biological Process positive regulation of myelinationSource:ARUK-UCL1 Publication
Biological Process positive regulation of oligodendrocyte differentiationSource:ARUK-UCL1 Publication
Biological Process pulmonary valve developmentSource:BHF-UCL1 Publication
Biological Process regulation of cytokine production involved in immune responseSource:ARUK-UCL1 Publication
Biological Process regulation of myelinationSource:ARUK-UCL1 Publication
Biological Process regulation of neuroinflammatory responseSource:ARUK-UCL1 Publication
Biological Process regulation of RNA biosynthetic processSource:ARUK-UCL1 Publication
Biological Process regulation of T cell cytokine productionSource:ARUK-UCL1 Publication
Biological Process regulation of T cell proliferationSource:ARUK-UCL1 Publication
Biological Process RNA destabilizationSource:MGI1 Publication
Cellular Location
Membrane
Topology
Extracellular: 23-258
Helical: 259-288
Cytoplasmic: 289-474
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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