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Mouse Anti-TLE1 Recombinant Antibody (IHC676) (CBMAB-MA247-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC676
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
TLE1 Transducin Like Enhancer Of Split 1
Introduction
TLE1 (Transducin Like Enhancer Of Split 1) is a protein coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology annotations related to this gene include identical protein binding and transcription factor binding.
Entrez Gene ID
7088
UniProt ID
Q04724
Alternative Names
Transducin Like Enhancer Of Split 1; Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila); Enhancer Of Split Groucho-Like Protein 1; ESG1; Transducin-Like Enhancer Protein 1; Enhancer Of Split Groucho 1; E(Sp1) Homolog; GRG1; ESG;
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity).
The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of anoikisSource:UniProtKB2 Publications
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process negative regulation of Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
PTM
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

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