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Mouse Anti-TIPIN Recombinant Antibody (CBYJT-3243) (CBMAB-T2526-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3243
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TIPIN (NP_060328) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIPIN Gene(Protein Coding) TIMELESS Interacting Protein
Introduction
TIPIN is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress.
Entrez Gene ID
54962
UniProt ID
Q9BVW5
Alternative Names
TIMELESS Interacting Protein; CSM3 Homolog (S. Cerevisiae)
Function
Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137).
Important for cell survival after DNA damage or replication stress (PubMed:17116885).
May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725).
Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725).
Biological Process
Biological Process cell cycle phase transitionSource:BHF-UCL1 Publication
Biological Process cell divisionSource:UniProtKB-KW
Biological Process DNA replication checkpoint signalingSource:HGNC-UCL1 Publication
Biological Process mitotic intra-S DNA damage checkpoint signalingSource:HGNC-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:HGNC-UCL1 Publication
Biological Process regulation of nuclear cell cycle DNA replicationSource:HGNC-UCL1 Publication
Biological Process replication fork arrestSource:GO_Central1 Publication
Biological Process replication fork protectionSource:GO_Central1 Publication
Biological Process response to UVSource:Ensembl
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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