Mouse Anti-THBS1 Recombinant Antibody (CBYJT-2939) (CBMAB-T2179-YJ)

Mouse

Human, Cattle, Dog, Horse, Mouse, Pig, Rat, Sheep

CBYJT-2939

IgG1

FC, IF, IHC, IP, WB

Reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets. MW of Antigen: ~450kD (non-reduced), 170-180kD (reduced). Epitope: Collagen Type V-binding domain of TSP

Human, Cattle, Dog, Horse, Mouse, Pig, Rat, Sheep

IgG1

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

PBS, pH 7.4

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

THBS1 Gene(Protein Coding) Thrombospondin 1

THBS1 is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. THBS1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to function in platelet aggregation, angiogenesis, and tumorigenesis.

Thrombospondin 1; Thrombospondin-1p180; TSP1; TSP; Thrombospondin-P50; Thrombospondin-1; THBS-1; TSP-1; THBS

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity).
Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Biological Process behavioral response to painSource:UniProtKB
Biological Process cell adhesionSource:BHF-UCL1 Publication
Biological Process cell migrationSource:BHF-UCL1 Publication
Biological Process cellular response to growth factor stimulusSource:Ensembl
Biological Process cellular response to heatSource:BHF-UCL1 Publication
Biological Process cellular response to tumor necrosis factorSource:Ensembl
Biological Process chronic inflammatory responseSource:BHF-UCL1 Publication
Biological Process engulfment of apoptotic cellSource:BHF-UCL1 Publication
Biological Process immune responseSource:BHF-UCL1 Publication
Biological Process inflammatory responseSource:CACAO1 Publication
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class IISource:BHF-UCL1 Publication
Biological Process negative regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process negative regulation of blood vessel endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process negative regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of cell-matrix adhesionSource:BHF-UCL1 Publication
Biological Process negative regulation of cGMP-mediated signalingSource:BHF-UCL1 Publication
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processSource:UniProtKB1 Publication
Biological Process negative regulation of dendritic cell antigen processing and presentationSource:BHF-UCL1 Publication
Biological Process negative regulation of endothelial cell chemotaxisSource:MGI1 Publication
Biological Process negative regulation of endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process negative regulation of endothelial cell proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process negative regulation of fibrinolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process negative regulation of focal adhesion assemblySource:BHF-UCL1 Publication
Biological Process negative regulation of interleukin-12 productionSource:BHF-UCL1 Publication
Biological Process negative regulation of long-chain fatty acid import across plasma membraneSource:BHF-UCL1 Publication
Biological Process negative regulation of nitric oxide mediated signal transductionSource:BHF-UCL1 Publication
Biological Process negative regulation of plasminogen activationSource:BHF-UCL1 Publication
Biological Process negative regulation of sprouting angiogenesisSource:BHF-UCL1 Publication
Biological Process peptide cross-linkingSource:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisSource:BHF-UCL2 Publications
Biological Process positive regulation of blood coagulationSource:BHF-UCL1 Publication
Biological Process positive regulation of blood vessel endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of chemotaxisSource:BHF-UCL1 Publication
Biological Process positive regulation of endothelial cell apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsSource:BHF-UCL1 Publication
Biological Process positive regulation of fibroblast migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage activationSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage chemotaxisSource:BHF-UCL
Biological Process positive regulation of MAP kinase activitySource:BHF-UCL1 Publication
Biological Process positive regulation of phosphorylationSource:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase B signalingSource:UniProtKB1 Publication
Biological Process positive regulation of reactive oxygen species metabolic processSource:BHF-UCL1 Publication
Biological Process positive regulation of smooth muscle cell proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta1 productionSource:BHF-UCL
Biological Process positive regulation of translationSource:BHF-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKB1 Publication
Biological Process response to calcium ionSource:BHF-UCL2 Publications
Biological Process response to endoplasmic reticulum stressSource:UniProtKB
Biological Process response to glucoseSource:BHF-UCL1 Publication
Biological Process response to hypoxiaSource:BHF-UCL1 Publication
Biological Process response to magnesium ionSource:BHF-UCL1 Publication
Biological Process response to mechanical stimulusSource:Ensembl
Biological Process response to progesteroneSource:BHF-UCL1 Publication
Biological Process response to testosteroneSource:Ensembl
Biological Process response to unfolded proteinSource:UniProtKB-KW
Biological Process response to xenobiotic stimulusSource:UniProtKB1 Publication
Biological Process sprouting angiogenesisSource:BHF-UCL1 Publication