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Mouse Anti-TFB2M Recombinant Antibody (CBYJT-2646) (CBMAB-T1825-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2646
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa297-397 from human TFB2M (NP_071761) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 297-397

Target

Full Name
transcription factor B2, mitochondrial
Introduction
TFB2M (Transcription Factor B2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to TFB2M include rRNA methyltransferase activity.
Entrez Gene ID
64216
UniProt ID
Q9H5Q4
Alternative Names
Transcription Factor B2, Mitochondrial; S-Adenosylmethionine-6-N, N-Adenosyl(RRNA) Dimethyltransferase 2; Hepatitis C Virus NS5A-Transactivated Protein 5; Mitochondrial Transcription Factor B2; Mitochondrial 12S RRNA Dimethylase 2; HCV NS5A-Transactivated Protein 5; H-MtTFB2; H-MtTFB
Function
S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033).
In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603, PubMed:15526033).
Stimulates transcription independently of the methyltransferase activity (PubMed:12897151).
Biological Process
Biological Process mitochondrial transcriptionSource:GO_Central1 Publication
Biological Process regulation of DNA-templated transcriptionSource:InterPro
Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process transcription initiation at mitochondrial promoterSource:UniProtKB2 Publications
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

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