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Rabbit Anti-Tacstd2 Recombinant Antibody (CBYJT-1801) (CBMAB-T0863-YJ)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYJT-1801
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Recombinant Mouse TROP-2 / TACSTD2 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TACSTD2
Introduction
Tacstd2 may play a role as a growth factor receptor.
Entrez Gene ID
56753
UniProt ID
Q8BGV3
Alternative Names
Ly97; EGP-1; TROP2; C80403; GA733-1
Function
May function as a growth factor receptor.
Biological Process
Biological Process negative regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Biological Process negative regulation of cell motilityISS:UniProtKB
Biological Process negative regulation of epithelial cell migrationISS:UniProtKB
Biological Process negative regulation of ruffle assemblyISS:UniProtKB
Biological Process negative regulation of stress fiber assemblyISS:UniProtKB
Biological Process negative regulation of substrate adhesion-dependent cell spreadingISS:UniProtKB
Biological Process positive regulation of stem cell differentiationIBA:GO_Central1 Publication
Biological Process regulation of epithelial cell proliferationIEA:Ensembl
Biological Process response to stimulusIEA:UniProtKB-KW
Biological Process ureteric bud morphogenesisIEA:Ensembl
Biological Process visual perceptionTAS:ProtInc1 Publication
Cellular Location
Membrane
Involvement in disease
Corneal dystrophy, gelatinous drop-like (GDLD):
A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.
Topology
Extracellular: 27-274
Helical: 275-297
Cytoplasmic: 298-323
PTM
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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