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Mouse Anti-TACR2 Recombinant Antibody (CBWJN-1691) (CBMAB-N4330-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1691
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tachykinin Receptor 2
Introduction
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6865
UniProt ID
P21452
Alternative Names
Tachykinin Receptor 2; Neurokinin A Receptor; NK-2 Receptor; NKNAR; TAC2R; NK-2R;
Function
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K> neuromedin-K> substance P.
Biological Process
Biological Process intestine smooth muscle contractionIEA:Ensembl
Biological Process muscle contractionTAS:ProtInc1 Publication
Biological Process negative regulation of luteinizing hormone secretionIEA:Ensembl
Biological Process operant conditioningIEA:Ensembl
Biological Process positive regulation of acetylcholine secretion, neurotransmissionIEA:Ensembl
Biological Process positive regulation of flagellated sperm motilityIMP:UniProtKB1 Publication
Biological Process positive regulation of smooth muscle contractionTAS:ProtInc1 Publication
Biological Process positive regulation of uterine smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vascular permeabilityIEA:Ensembl
Biological Process prolactin secretionIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayTAS:ProtInc1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 1-32
Helical: 33-56
Cytoplasmic: 57-69
Helical: 70-90
Extracellular: 91-107
Helical: 108-129
Cytoplasmic: 130-149
Helical: 150-170
Extracellular: 171-196
Helical: 197-218
Cytoplasmic: 219-251
Helical: 252-272
Extracellular: 273-290
Helical: 291-310
Cytoplasmic: 311-398
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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