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Rabbit Anti-STXBP1 Recombinant Antibody (D4O6V) (CBMAB-CP1612-LY)

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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D4O6V
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr157 of human Munc18-1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
syntaxin binding protein 1
Entrez Gene ID
Human6812
Mouse20910
Rat25558
UniProt ID
HumanP61764
MouseO08599
RatP61765
Function
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity).
Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Biological Process
Biological Process axon target recognitionISS:UniProtKB
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process developmental process involved in reproductionIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic depressionIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process negative regulation of protein-containing complex assemblyIEA:Ensembl
Biological Process negative regulation of synaptic transmission, GABAergicISS:UniProtKB
Biological Process neuromuscular synaptic transmissionIEA:Ensembl
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process platelet aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process platelet degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of calcium ion-dependent exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretion, neurotransmissionIEA:Ensembl
Biological Process positive regulation of mast cell degranulationIEA:Ensembl
Biological Process positive regulation of vesicle dockingIEA:Ensembl
Biological Process presynaptic dense core vesicle exocytosisIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein stabilizationIEA:Ensembl
Biological Process regulation of acrosomal vesicle exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of SNARE complex assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of synaptic vesicle primingISS:UniProtKB
Biological Process response to estradiolIEA:Ensembl
Biological Process SNARE complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptic vesicle maturationISS:UniProtKB
Biological Process synaptic vesicle primingIEA:Ensembl
Biological Process vesicle docking involved in exocytosisISS:ParkinsonsUK-UCL
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Membrane
Involvement in disease
Developmental and epileptic encephalopathy 4 (DEE4):
A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Affected individuals have neonatal or infantile onset of seizures, profound intellectual disability, and MRI evidence of brain hypomyelination.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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