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Mouse Anti-STAM Recombinant Antibody (29C678) (CBMAB-S0237-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
29C678
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to amino acids 149-165 of human STAM
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Introduction
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.
Entrez Gene ID
8027
UniProt ID
Q92783
Alternative Names
STAM-1; STAM1
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
(Microbial infection) Plays an important role in Dengue virus entry.
Biological Process
Biological Process macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process membrane fission1 PublicationIC:ComplexPortal
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Early endosome membrane
PTM
Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
Ubiquitinated by ITCH.
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For research use only. Not intended for any clinical use.

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