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Mouse Anti-ST6GAL1 Recombinant Antibody (CBWJC-4464) (CBMAB-C5855WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-4464
Antibody Isotype
IgM
Application
FC, IF, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50 mM sodium borate, 150 mM sodium chloride, 20% glycerol, pH 8.0
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Introduction
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6480
UniProt ID
P15907
Alternative Names
ST6N; SIAT1; ST6GalI
Function
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Biological Process
Biological Process humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-acetylneuraminate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemotaxisIEA:Ensembl
Biological Process negative regulation of macrophage apoptotic processIEA:Ensembl
Biological Process O-glycan processingTAS:Reactome
Biological Process positive regulation of mononuclear cell proliferationIEA:Ensembl
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sialylationIEA:Ensembl
Biological Process regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process sialylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Topology
Cytoplasmic: 1-9
Helical: 10-26
Lumenal: 27-406
PTM
The soluble form derives from the membrane form by proteolytic processing.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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