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Mouse Anti-ST14 Recombinant Antibody (CBFYM-0144) (CBMAB-M0165-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0144
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
suppression of tumorigenicity 14 (colon carcinoma)
Introduction
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate.
Entrez Gene ID
6768
UniProt ID
Q9Y5Y6
Alternative Names
HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14
Function
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
Biological Process
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process keratinocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neural tube closureIEA:Ensembl
Biological Process protein catabolic processIEA:Ensembl
Biological Process proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Involvement in disease
Ichthyosis, congenital, autosomal recessive 11 (ARCI11):
A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
Topology
Cytoplasmic: 1-55
Helical: 56-76
Extracellular: 77-855
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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