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Mouse Anti-SRRM1 Recombinant Antibody (CBXS-2196) (CBMAB-S4958-CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2196
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine And Arginine Repetitive Matrix 1
Introduction
SRRM1 (Serine And Arginine Repetitive Matrix 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination.
Entrez Gene ID
Human10250
Mouse51796
Rat313620
UniProt ID
HumanQ8IYB3
MouseQ52KI8
RatB2RYB3
Alternative Names
Serine And Arginine Repetitive Matrix 1; Ser/Arg-Related Nuclear Matrix Protein; SR-Related Nuclear Matrix Protein Of 160 KDa; Serine/Arginine Repetitive Matrix 1; SRM160; Serine/Arginine Repetitive Matrix Protein 1; Plenty Of Prolines 101-Like; 160-KD; POP101;
Function
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Biological Process
Biological Process localizationManual Assertion Based On ExperimentIDA:DisProt
Biological Process mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus matrix
Nucleus speckle
PTM
Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724).
Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724).
Citrullinated by PADI4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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