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Mouse Anti-SOHLH1 Monoclonal Antibody (2B1) (CBMAB-0151-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B1
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SOHLH1
Introduction
This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development.
Entrez Gene ID
402381
UniProt ID
Q5JUK2
Alternative Names
bA100C15.3; bHLHe80; C9orf157; NOHLH; SPATA27; TEB2
Function
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
Biological Process
Biological Process cell differentiationISS:UniProtKB
Biological Process oocyte differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisISS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Spermatogenic failure 32 (SPGF32):
An autosomal dominant infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia.
Ovarian dysgenesis 5 (ODG5):
A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. ODG5 is an autosomal recessive condition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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