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Mouse Anti-SMAD9 Monoclonal Antibody (2F4) (CBMAB-0128-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F4
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SMAD9
Introduction
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene. Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members.
Entrez Gene ID
4093
UniProt ID
O15198
Alternative Names
MADH6; MADH9
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:BHF-UCL
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to BMP stimulus1 PublicationNAS:BHF-UCL
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Involvement in disease
Pulmonary hypertension, primary, 2 (PPH2):
A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
PTM
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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