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Rabbit Anti-SLC4A1 Recombinant Antibody (D3X1R) (CBMAB-CP2474-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
D3X1R
Antibody Isotype
IgG
Application
IF, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala176 of human AE1 protein.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 4
Entrez Gene ID
Mouse20533
Rat24779
UniProt ID
MouseP04919
RatP23562
Alternative Names
Ae1; CD233; Empb3; l11Jus51
Function
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
(Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes.
Biological Process
Biological Process anion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process bicarbonate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process blood coagulationIEA:Ensembl
Biological Process cellular ion homeostasisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process chloride transportISS:UniProtKB
Biological Process erythrocyte developmentIEA:Ensembl
Biological Process ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of glycolytic process through fructose-6-phosphateIEA:Ensembl
Biological Process negative regulation of oxidoreductase activityIEA:Ensembl
Biological Process negative regulation of urine volumeIEA:Ensembl
Biological Process pH elevationIEA:Ensembl
Biological Process plasma membrane phospholipid scramblingIEA:Ensembl
Biological Process protein localization to plasma membraneIEA:Ensembl
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Basolateral cell membrane
Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.
Involvement in disease
Ovalocytosis, Southeast Asian (SAO):
A hereditary hematologic disorder characterized by ovalocytic erythrocytes that are rigid and exhibit reduced expression of many erythrocyte antigens. Clinical manifestations include mild hemolysis, intermittent jaundice and gallstones. However, the disorder is most often asymptomatic.
Spherocytosis 4 (SPH4):
Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal.
Renal tubular acidosis, distal, 1 (DRTA1):
An autosomal dominant disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.
Renal tubular acidosis, distal, 4, with hemolytic anemia (DRTA4):
An autosomal recessive disease characterized by the association of hemolytic anemia with distal renal tubular acidosis, the reduced ability to acidify urine resulting in variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis.
Renal tubular acidosis, distal, with normal red cell morphology (dRTA-NRC):
A disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.
Cryohydrocytosis (CHC):
An autosomal dominant disorder of red cell membrane permeability characterized by cold-induced changes in cell volume, resulting in cold-sensitive stomatocytosis, and increased erythrocyte osmotic fragility and autohemolysis at 4 degrees Celsius. Patients present with mild to moderate hemolytic anemia, splenomegaly, fatigue, and pseudohyperkalemia due to a potassium leak from the erythrocytes.
PTM
Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation.
Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation.
N-glycosylated.
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For research use only. Not intended for any clinical use.

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