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Mouse Anti-SLC25A24 Recombinant Antibody (CBXS-3666) (CBMAB-S0945-CQ)


See all SLC25A24 antibodies
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3666
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tissue culture supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLC25A24
Introduction
This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
29957
UniProt ID
Q6NUK1
Alternative Names
Solute Carrier Family 25 Member 24; Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24; Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 1; Small Calcium-Binding Mitochondrial Carrier Protein 1; Mitochondrial ATP-Mg/Pi Carrier Protein 1; APC1; Calcium-Binding Mitochondrial Carrier Protein SCaMC-1;
Function
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.
Biological Process
Biological Process ATP transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to calcium ionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Fontaine progeroid syndrome (FPS):
An autosomal dominant progeroid disorder characterized by prenatal and postnatal growth retardation, decreased subcutaneous fat tissue, wrinkled skin, an aged appearance since birth, an abnormal scalp hair pattern, sparse hair, hypoplastic distal phalanges with hypoplastic nails, a widely open anterior fontanel, facial dysmorphisms, and craniosynostosis. Early death is observed in some patients.
Topology
Mitochondrial intermembrane: 1-197
Helical: 198-215
Mitochondrial matrix: 216-252
Helical: 253-272
Mitochondrial intermembrane: 273-295
Helical: 296-309
Mitochondrial matrix: 310-345
Helical: 346-365
Mitochondrial intermembrane: 366-388
Helical: 389-406
Mitochondrial matrix: 407-445
Helical: 446-465
Mitochondrial intermembrane: 466-477
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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