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Mouse Anti-SLA2 Recombinant Antibody (CBXS-4075) (CBMAB-S1333-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4075
Antibody Isotype
IgG2b
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Src Like Adaptor 2
Introduction
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.
Entrez Gene ID
84174
UniProt ID
Q9H6Q3
Alternative Names
Src Like Adaptor 2; Modulator Of Antigen Receptor Signaling; C20orf156; SLAP-2; SLAP2; MARS;
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Biological Process
Biological Process antigen receptor-mediated signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process B cell mediated immunityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune response1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Isoform 1
Cell membrane
Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2
Cytoplasm
May be cytoplasmic and is not localized to membranes.
PTM
Phosphorylated by CSF1R.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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