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Rabbit Anti-SIRT5 Recombinant Antibody (CBXS-5409) (CBMAB-S2621-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey
Clone
CBXS-5409
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sirtuin 5
Introduction
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
Human23408
Mouse68346
Monkey700855
UniProt ID
HumanQ9NXA8
MouseQ8K2C6
MonkeyF7EZ75
Alternative Names
Sirtuin 5; SIR2L5; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae); Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5; NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial; Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5; NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial;
Function
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469).
Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693).
Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062).
Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).
Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity).
Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Biological Process
Biological Process mitochondrion organizationTAS:Reactome
Biological Process negative regulation of cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process negative regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine demalonylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine desuccinylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ADP-ribosylationBy SimilarityISS:GO_Central
Biological Process protein deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein deglutarylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein demalonylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein desuccinylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of ketone biosynthetic processISS:UniProtKB
Biological Process response to nutrient levelsIEA:Ensembl
Cellular Location
Mitochondrion matrix
Mitochondrion intermembrane space
Cytoplasm, cytosol
Nucleus
Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
Isoform 1
Cytoplasm
Mitochondrion
Isoform 2
Mitochondrion
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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