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Rat Anti-SERPINF2 Recombinant Antibody (CBXS-4655) (CBMAB-S1894-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-4655
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse recombinant protein of Serpin F2
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family F Member 2
Introduction
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
18816
UniProt ID
Q61247
Alternative Names
AI747498; Pli; Serpimf2
Function
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
Biological Process
Acute-phase response
Blood vessel morphogenesis
Collagen fibril organization
Fibrinolysis
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Negative regulation of endopeptidase activity
Negative regulation of fibrinolysis
Negative regulation of plasminogen activation
Platelet degranulation
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of cell differentiation
Positive regulation of collagen biosynthetic process
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of JNK cascade
Positive regulation of smooth muscle cell proliferation
Positive regulation of stress fiber assembly
Positive regulation of transcription by RNA polymerase II
Positive regulation of transforming growth factor beta production
Response to organic substance
Cellular Location
Secreted
Involvement in disease
An autosomal recessive disorder resulting in severe hemorrhagic diathesis.
PTM
Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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