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Mouse Anti-SERPINB3 Recombinant Antibody (CBXS-4799) (CBMAB-S2025-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Dog
Clone
CBXS-4799
Antibody Isotype
IgG1
Application
WB, IHC, IHC-P

Basic Information

Immunogen
Recombinant full length human SERPINB3 (NP_008850)
Specificity
Human, Rat, Dog
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family B Member 3
Introduction
SERPINB3 (Serpin Family B Member 3) is a Protein Coding gene. Diseases associated with SERPINB3 include Anus Cancer and Cervical Squamous Cell Carcinoma. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB4.
Entrez Gene ID
Human6317
Rat304688
UniProt ID
HumanP29508
RatQ6IE44
Alternative Names
Serpin Family B Member 3; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 3; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3; Squamous Cell Carcinoma Antigen 1; Protein T4-A; SCCA-1; SCCA1; Serpin B3;
Function
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH2-terminal kinase (JNK1).
Biological Process
Biological Process autocrine signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of catalytic activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of peptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process paracrine signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Seems to also be secreted in plasma by cancerous cells but at a low level.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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