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Mouse Anti-SENP7 Recombinant Antibody (CBXS-4494) (CBMAB-S1736-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4494
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF

Basic Information

Immunogen
SENP7 (NP_065705, 1 a.a.-110 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/sentrin specific peptidase 7
Introduction
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).
Entrez Gene ID
57337
UniProt ID
Q9BQF6
Alternative Names
SUMO1/Sentrin Specific Peptidase 7; Sentrin/SUMO-Specific Protease SENP7; SUMO1/Sentrin Specific Protease 7; SUMO-1-Specific Protease 2; EC 3.4.22.-; KIAA1707; SUSP2; SSP2;
Function
Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity).
Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455).
Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455).
Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455).
Biological Process
Biological Process antiviral innate immune responseISS:UniProtKB
Biological Process protein desumoylationISS:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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