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Rabbit Anti-SENP3 Recombinant Antibody (CBXS-5358) (CBMAB-S2571-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBXS-5358
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/Sentrin/SMT3 Specific Peptidase 3
Introduction
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
Entrez Gene ID
Human26168
Mouse80886
Rat303245
Monkey715884
UniProt ID
HumanQ9H4L4
MouseQ9EP97
RatQ3MID8
MonkeyF7HGI8
Alternative Names
SUMO1/Sentrin/SMT3 Specific Peptidase 3; SUMO-1-Specific Protease 3; SSP3; SUMO1/Sentrin/SMT3 Specific Protease 3; Sentrin/SUMO-Specific Protease SENP3; Sentrin/SUMO-Specific Protease 3; Sentrin-Specific Protease 3;
Function
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608).
Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823).
Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085).
Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224).
Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314).
Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216).
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859).
Deconjugates SUMO2 from KAT5 (PubMed:32832608).
Biological Process
Protein desumoylation
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Cytoplasm
Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224).
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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