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Rabbit Anti-S100A11 Recombinant Antibody (CBXS-3644) (CBMAB-S0924-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-3644
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human S100A11/S100C protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
S100 Calcium Binding Protein A11
Introduction
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
Entrez Gene ID
6282
UniProt ID
P31949
Alternative Names
S100 Calcium Binding Protein A11; Metastatic Lymph Node Gene 70 Protein; Protein S100-C; Calgizzarin; MLN 70; MLN70; S100C;
Function
Facilitates the differentiation and the cornification of keratinocytes.
Biological Process
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
PTM
Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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