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Mouse Anti-S100A1 Recombinant Antibody (S100A1/1942) (CBMAB-S6506-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
S100A1/1942
Antibody Isotype
IgG1, κ
Application
IF, IHC-P

Basic Information

Immunogen
Recombinant human Full length S100A1 protein
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
S100 Calcium Binding Protein A1
Introduction
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
Entrez Gene ID
6271
UniProt ID
P23297
Alternative Names
S100 Calcium Binding Protein A1; S100 Calcium-Binding Protein A1; S-100 Protein Subunit Alpha; S-100 Protein Alpha Chain; S100A; S100 Protein, Alpha Polypeptide;
Function
Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Biological Process
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of heart contraction1 PublicationNAS:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cytoplasm
Sarcoplasmic reticulum
Mitochondrion
PTM
Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
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For research use only. Not intended for any clinical use.

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