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Mouse Anti-RNFT1 Recombinant Antibody (4H7) (CBMAB-R3052-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4H7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-101 from human LOC51136 (NP_057209) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ring Finger Protein, Transmembrane 1
Introduction
RNFT1 (Ring Finger Protein, Transmembrane 1) is a Protein Coding gene. Diseases associated with RNFT1 include Spermatogenic Failure, X-Linked, 1. An important paralog of this gene is RNFT2.
Entrez Gene ID
51136
UniProt ID
Q5M7Z0
Alternative Names
Ring Finger Protein, Transmembrane 1; RING Finger And Transmembrane Domain-Containing Protein 1; E3 Ubiquitin-Protein Ligase RNFT1; Protein PTD016; EC 2.3.2.27; PTD016;
Function
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
Biological Process
Biological Process positive regulation of ERAD pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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