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Mouse Anti-RBP3 Recombinant Antibody (CBCNR-327) (CBMAB-R1796-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-327
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
retinol binding protein 3, interstitial
Introduction
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5949
UniProt ID
P10745
Alternative Names
Retinol Binding Protein 3; Interphotoreceptor Retinoid-Binding Protein; IRBP; Retinol-Binding Protein 3, Interstitial; Retinol Binding Protein 3, Interstitial; Interstitial Retinol-Binding Protein 3; Interstitial Retinol Binding Protein 3; Interstitial Retinol-Binding Protein;
Function
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Biological Process
Biological Process lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process proteolysisIEA:InterPro
Biological Process retinoid metabolic processTAS:Reactome
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix
Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Involvement in disease
Retinitis pigmentosa 66 (RP66):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

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