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Mouse Anti-RBFOX1 Recombinant Antibody (CBXF-1026) (CBMAB-F1313-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
CBXF-1026
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Purified human recombinant protein fragment structure from E. coli. corresponding to N terminal amino acids 1-100 of Human FOX1
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
10 mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA binding protein fox-1 homolog 1
Introduction
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human54715
Mouse268859
Rat302920
Cattle521304
UniProt ID
HumanQ9NWB1
MouseQ9JJ43
RatD3ZSL1
CattleA0A3Q1MF95
Alternative Names
RNA Binding Fox-1 Homolog 1; RNA Binding Protein, Fox-1 Homolog 1; Hexaribonucleotide-Binding Protein 1; Ataxin 2-Binding Protein 1; Fox-1 Homolog A; HRNBP1; A2BP1; FOX1; Hexaribonucleotide Binding Protein 1 Isoform Alpha; RNA Binding Protein, Fox-1 Homolog (C. Elegans) 1;
Function
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Biological Process
mRNA processing
Nervous system development
Regulation of alternative mRNA splicing, via spliceosome
RNA splicing
RNA transport
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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