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Mouse Anti-PYGB Recombinant Antibody (CBLG1-2427) (CBMAB-G6515-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2427
Antibody Isotype
IgG1
Application
ELISA, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.1% sodium azide
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycogen Phosphorylase, Muscle Associated
Introduction
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
Entrez Gene ID
5834
UniProt ID
P11216
Alternative Names
GPBB
Function
Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852).
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228).
Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228).
However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).
Biological Process
Glycogen catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
azurophil granule lumen
cytoplasm
extracellular exosome
extracellular region
membrane
PTM
Phosphorylated (PubMed:27402852).
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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