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Mouse Anti-PSMB9 Recombinant Antibody (1D1) (CBMAB-P3191-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D1
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 21-219 of human PSMB9(NP_002791) produced in E. coli.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome subunit beta 9
Introduction
PSMB9 (Proteasome Subunit Beta 9) is a protein coding gene. Diseases associated with PSMB9 include Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma andNasopharyngeal Disease. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include threonine-type endopeptidase activity. An important paralog of the gene is PSMB6.
Entrez Gene ID
5698
UniProt ID
P28065
Alternative Names
Lmp-2; Lmp2
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
Biological Process
Immune system processIEA:UniProtKB-KW
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Proteasome-associated autoinflammatory syndrome 3 (PRAAS3):
An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic.
PTM
Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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