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Recombinant Rat Anti-PROCR Antibody (CBHb217) (CBMAB-Hb461-LY)


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Summary

Host Animal
Rat
Specificity
Human
Clone
CBHb217
Antibody Isotype
IgG1
Application
FC, FuncS, IP, WB

Basic Information

Immunogen
Human EPCR-positive RE-1 cells
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% BSA
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein C receptor, endothelial (EPCR)
Entrez Gene ID
10544
UniProt ID
Q9UNN8
Alternative Names
Activated protein C receptor, CD201, Endothelial cell protein C receptor
Gene name: PROCR
Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Biological Process
Blood coagulationIEA:UniProtKB-KW
Negative regulation of coagulationManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Membrane
Involvement in disease
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Topology
Extracellular: 18-210
Helical: 211-231
Cytoplasmic: 232-238
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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