Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PRLR Recombinant Antibody (1E4) (CBMAB-A7070-LY)


See all PRLR antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E4
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
PRLR (NP_000940.1, 371 a.a. ~ 479 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PRLR
Entrez Gene ID
5618
UniProt ID
P16471
Alternative Names
hPRLrI
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Biological Process
Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of transmembrane receptor protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Embryo implantationManual Assertion Based On ExperimentTAS:ProtInc
LactationManual Assertion Based On ExperimentTAS:ProtInc
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland epithelial cell differentiationIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Oncostatin-M-mediated signaling pathwayIEA:GOC
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Prostate gland growthIEA:Ensembl
Receptor signaling pathway via JAK-STATIEA:Ensembl
Regulation of cell adhesionIEA:Ensembl
Regulation of epithelial cell differentiationIEA:Ensembl
Response to bacteriumIEA:Ensembl
Steroid biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Isoform 7
Secreted
Involvement in disease
Multiple fibroadenomas of the breast (MFAB):
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Hyperprolactinemia (HPRL):
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
Topology
Extracellular: 25-234
Helical: 235-258
Cytoplasmic: 259-622
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRLR Recombinant Antibody (1E4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry