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Mouse Anti-POLL Recombinant Antibody (1H4) (CBMAB-0844-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant 18.9 kDa protein fragment of POLL
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POLL
Introduction
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This protein is involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA.
Entrez Gene ID
27343
UniProt ID
Q9UGP5
Alternative Names
BETAN; POLKAPPA
Function
DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067).
Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195).
Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067).
Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195).
Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).
Biological Process
Base-excision repair, gap-fillingManual Assertion Based On ExperimentIDA:UniProtKB
DNA biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
DNA replication1 PublicationNAS:UniProtKB
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:UniProtKB
Nucleotide-excision repairManual Assertion Based On ExperimentIDA:UniProtKB
Somatic hypermutation of immunoglobulin genes1 PublicationNAS:UniProtKB
Cellular Location
Nucleus
Chromosome
Accumulates at sites of DNA damage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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