Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PMP2 Recombinant Antibody (CBXF-3881) (CBMAB-F1958-CQ)


See all PMP2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3881
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
E. coli-derived recombinant human FABP8/M-FABP Ser2-Val132
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% trehalose
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peripheral Myelin Protein 2
Introduction
MyelinP2 protein, also known as PMP2, is a cytosolic protein found primarily inperipheral nerves. It Belongs to the calycin superfamily. Fatty-acidbinding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipidbinding protein of peripheral myelin. It is similar in amino acid sequence andtertiary structure to fatty acid binding proteins found in the liver,adipocytes, and intestine, its expression is limited to the nervous system.PMP2 is detected only in myelin-producing cells of the central and peripheralnervous systems, the oligodendrocytes and Schwann cells, respectively. PMP2 mayplay a role in lipid transport protein in Schwann cells. It forms a beta-barrelstructure that accommodates hydrophobic ligands in its interior.
Entrez Gene ID
5375
UniProt ID
P02689
Alternative Names
FABP8, M-FABP, MP2, P2
Function
May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
Biological Process
Fatty acid transportManual Assertion Based On ExperimentIBA:GO_Central
Membrane organizationIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Charcot-Marie-Tooth disease, demyelinating, 1G (CMT1G):
An autosomal dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1G is characterized by distal muscle weakness and atrophy with onset in the first or second decade.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PMP2 Recombinant Antibody (CBXF-3881)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:

Submit A Review

Online Inquiry