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Rabbit Anti-PLAUR Recombinant Antibody (D7X2N) (CBMAB-C4126-CN)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D7X2N
Application
WB, IF

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
PLAUR
Introduction
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Entrez Gene ID
5329
UniProt ID
Q03405
Alternative Names
CD87; UPAR; URKR; U-PAR
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of proteolysis1 PublicationNAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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