Mouse Anti-PCDHGA9 Recombinant Antibody (1G10) (CBMAB-P1025-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1G10

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

PCDHGA9 (NP_061744, 356-445 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

protocadherin gamma subfamily A, 9

Introduction

PCDHGA9 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Entrez Gene ID

56107

UniProt ID

Q9Y5G4

Alternative Names

Protocadherin Gamma Subfamily A, 9; PCDH-GAMMA-A9; Protocadherin Gamma-A9;

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Biological Process

Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 29-692
Helical: 693-713
Cytoplasmic: 714-932

More Infomation

References

Wang, H., Guan, W., Zhang, X., Wu, Y., Ou, Y., Zhang, Y., ... & Yao, H. (2024). TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9. Cancer Biotherapy & Radiopharmaceuticals.

Zhou, Z., Lai, Y., Cao, S., Zhuo, Q., & Tang, H. (2021). Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9. Molecular medicine reports, 24(6), 1-11.

Weng, J., Li, S., Lin, H., Mei, H., Liu, Y., Xiao, C., ... & Wen, Y. (2020). PCDHGA9 represses epithelial-mesenchymal transition and metastatic potential in gastric cancer cells by reducing β-catenin transcriptional activity. Cell death & disease, 11(3), 206.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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