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Mouse Anti-PAX7 Antibody (PAX7) (CBMAB-0889-YC)


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Summary

Host Animal
Mouse
Specificity
Chicken, Amphibian, Avian, Cattle, Dog, Fish, Goat, Human, Mouse, Sheep, Pig, Rat, Turtle, Frog, Zebrafish
Clone
PAX7
Antibody Isotype
IgG1, ĸ
Application
ChIP, FC, FFPE, IF, IHC, IP, WB

Basic Information

Immunogen
Recombinant protein (C-terminal region, aa 352-523)
Specificity
Chicken, Amphibian, Avian, Cattle, Dog, Fish, Goat, Human, Mouse, Sheep, Pig, Rat, Turtle, Frog, Zebrafish
Antibody Isotype
IgG1, ĸ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in C-terminal region (aa 418-427)

Target

Full Name
Pax7
Introduction
PAX7 (pax7) is a member of the paired box (PAX) family of transcription factors. The PAX proteins play critical roles during fetal development and cancer growth. PAX7 is speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma.
Entrez Gene ID
Human5081
Mouse18509
Rat500574
Chicken395942
Zebrafish30587
Dog487408
Goat102172220
Sheep101106413
Pig100625823
Frog100496502
UniProt ID
HumanP23759
MouseP47239
RatD3ZRA8
ChickenO42349
ZebrafishO57418
CattleE1BKL5
DogF1PNX6
GoatA0A452FU61
SheepA0A6P7DTE3
PigA0A1S6QCC5
FrogA0A803JB48
Alternative Names
PAX-7
Function
Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ developmentIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Rhabdomyosarcoma 2 (RMS2):
A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Myopathy, congenital, progressive, with scoliosis (MYOSCO):
An autosomal recessive muscular disorder characterized by infantile onset of progressive muscular atrophy, hypotonia, ptosis, scoliosis and dysmorphic facial features. Disease severity is variable, ranging from mild to severe.
More Infomation

Manceau, L., Richard Albert, J., Lollini, P. L., Greenberg, M. V., Gilardi-Hebenstreit, P., & Ribes, V. (2022). Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs. PLoS Genetics, 18(5), e1009782.

Nord, H., Kahsay, A., Dennhag, N., Pedrosa Domellöf, F., & von Hofsten, J. (2022). Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation. Developmental Dynamics, 251(9), 1423-1438.

Choi, J. H., Han, D. H., & Gong, S. P. (2021). Cloning and characterization of a cDNA encoding a paired box protein, PAX7, from black sea bream, Acanthopagrus schlegelii. Journal of Animal Reproduction and Biotechnology, 36(4), 314-322.

Wang, M., Song, W., Jin, C., Huang, K., Yu, Q., Qi, J., ... & He, Y. (2021). Pax3 and pax7 exhibit distinct and overlapping functions in marking muscle satellite cells and muscle repair in a marine teleost, sebastes schlegelii. International Journal of Molecular Sciences, 22(7), 3769.

Park, H. J., Lee, W. Y., Lee, R., Park, J. K., Hong, K. H., Park, C., & Song, H. (2020). Expression of paired box protein PAX7 in prepubertal boar testicular gonocytes. Acta Histochemica, 122(6), 151595.

Al Tanoury, Z., Rao, J., Tassy, O., Gobert, B., Gapon, S., Garnier, J. M., ... & Pourquié, O. (2020). Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro. Development, 147(12), dev187344.

Feichtinger, R. G., Mucha, B. E., Hengel, H., Orfi, Z., Makowski, C., Dort, J., ... & Dumont, N. A. (2019). Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genetics in Medicine, 21(11), 2521-2531.

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For research use only. Not intended for any clinical use.

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