Mouse Anti-PAK1IP1 Recombinant Antibody (CBYC-P144) (CBMAB-P0693-YC)

Name: Mouse Anti-PAK1IP1 Recombinant Antibody (CBYC-P144)
SKU: CBMAB-P0693-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Rat

Clone

CBYC-P144

Antibody Isotype

IgM

Application

Basic Information

Specificity

Human, Rat

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

PAK1 Interacting Protein 1

Introduction

PAK1IP1 has ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues.

Entrez Gene ID

Human	55003
Rat	361232

UniProt ID

Human	Q9NWT1
Rat	Q32PZ0

Alternative Names

PAK1 Interacting Protein 1; WD Repeat-Containing Protein 84; PAK/PLC-Interacting Protein 1; WDR84; HPIP1; PIP1;

Function

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).

Biological Process

Cell population proliferationIEA:Ensembl
Negative regulation of signal transductionIEA:UniProtKB-KW
Regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Roof of mouth developmentIEA:Ensembl

Cellular Location

Nucleus, nucleolus

More Infomation

References

Panoutsopoulos, A. A., De Crescenzo, A. H., Lee, A., Lu, A. M., Ross, A. P., Borodinsky, L. N., ... & Zarbalis, K. S. (2020). Pak1ip1 loss-of-function leads to cell cycle arrest, loss of neural crest cells, and craniofacial abnormalities. Frontiers in cell and developmental biology, 8, 510063.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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