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Mouse Anti-PAFAH2 Recombinant Antibody (1A8) (CBMAB-P0666-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
platelet-activating factor acetylhydrolase 2, 40kDa
Introduction
PAFAH2 is platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.
Entrez Gene ID
5051
UniProt ID
Q99487
Alternative Names
Platelet Activating Factor Acetylhydrolase 2; Platelet-Activating Factor Acetylhydrolase 2, 40kDa; Serine-Dependent Phospholipase A2; EC 3.1.1.47; HSD-PLA2; SD-PLA2; Platelet-Activating Factor Acetylhydrolase 2, Cytoplasmic; Platelet-Activating Factor Acetylhydrolase 2 (40kD); EC 3.1.1;
Function
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101).
Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity).
Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity).
Biological Process
Blood coagulationTAS:Reactome
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Membrane
Endoplasmic reticulum membrane
In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress.
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For research use only. Not intended for any clinical use.

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