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Mouse Anti-OVOL2 Recombinant Antibody (CBXO-0340) (CBMAB-O0784-CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXO-0340
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
OVOL2
Introduction
This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy.
Entrez Gene ID
Human5013
Mouse18423
Rat25646
UniProt ID
HumanP32242
MouseP80205
RatQ63410
Alternative Names
Ovo Like Zinc Finger 2; Zinc Finger Protein 339; Corneal Endothelial Dystrophy 1 (Autosomal Dominant); ZNF339; Transcription Factor Ovo-Like 2; Ovo-Like 2 (Drosophila); EUROIMAGE566589
Function
Zinc-finger transcription repressor factor (PubMed:19700410).
Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity).
Positively regulates neuronal differentiation (By similarity).
Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410).
Important for the correct development of primordial germ cells in embryos (By similarity).
Biological Process
AngiogenesisIEA:Ensembl
Cellular response to transforming growth factor beta stimulusISS:ARUK-UCL
Dorsal/ventral pattern formationIEA:Ensembl
Embryonic digestive tract morphogenesisIEA:Ensembl
Endocardium formationIEA:Ensembl
Epidermal cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Heart loopingIEA:Ensembl
Heart trabecula formationIEA:Ensembl
Labyrinthine layer blood vessel developmentIEA:Ensembl
Negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Negative regulation of gene expressionISS:ARUK-UCL
Negative regulation of keratinocyte differentiationIMP:BHF-UCL
Negative regulation of Notch signaling pathwayIDA:BHF-UCL
Negative regulation of stem cell proliferationIEA:Ensembl
Negative regulation of transcription by competitive promoter bindingIDA:BHF-UCL
Neural crest cell migrationIEA:Ensembl
Neural fold formationIEA:Ensembl
Positive regulation of gene expressionISS:ARUK-UCL
Positive regulation of keratinocyte differentiationIEA:Ensembl
Regulation of cell cycleIMP:BHF-UCL
Regulation of keratinocyte proliferationIMP:BHF-UCL
Regulation of SMAD protein signal transductionISS:ARUK-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Corneal dystrophy, posterior polymorphous, 1 (PPCD1):
A rare corneal disorder characterized by small aggregates of apparent vesicles bordered by a gray haze at the level of Descemet membrane, an altered corneal endothelial cell structure, and an unusual proliferation of endothelial cells. Symptoms can range from very aggressive to asymptomatic and non-progressive, even within the same family.
More Infomation

Jiang, Y., & Zhang, Z. (2023). OVOL2: an epithelial lineage determiner with emerging roles in energy homeostasis. Trends in Cell Biology.

Zhong, X., Peddada, N., Wang, J., Moresco, J. J., Zhan, X., Shelton, J. M., ... & Beutler, B. (2023). OVOL2 sustains postnatal thymic epithelial cell identity. Nature communications, 14(1), 7786.

Zhang, Z., Jiang, Y., Su, L., Ludwig, S., Zhang, X., Tang, M., ... & Beutler, B. (2022). Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. Cell metabolism, 34(11), 1860-1874.

Zhang, X., Luo, F., Luo, S., Li, L., Ren, X., Lin, J., ... & Ye, Q. (2022). Transcriptional repression of aerobic glycolysis by OVOL2 in breast cancer. Advanced Science, 9(27), 2200705.

Zhang, R., Geng, G. J., Guo, J. G., Mi, Y. J., Zhu, X. L., Li, N., ... & Jiang, J. (2022). An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer. Cell Communication and Signaling, 20(1), 40.

Gugnoni, M., Manzotti, G., Vitale, E., Sauta, E., Torricelli, F., Reggiani, F., ... & Ciarrocchi, A. (2022). OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer. Journal of Experimental & Clinical Cancer Research, 41(1), 108.

Murata, M., Ito, T., Tanaka, Y., Yamamura, K., Furue, K., & Furue, M. (2020). OVOL2-mediated ZEB1 downregulation may prevent promotion of actinic keratosis to cutaneous squamous cell carcinoma. Journal of Clinical Medicine, 9(3), 618.

Haensel, D., Sun, P., MacLean, A. L., Ma, X., Zhou, Y., Stemmler, M. P., ... & Dai, X. (2019). An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO reports, 20(1), e46273.

Watanabe, K., Liu, Y., Noguchi, S., Murray, M., Chang, J. C., Kishima, M., ... & Suzuki, H. (2019). OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages. Scientific Reports, 9(1), 6490.

Kitazawa, K., Hikichi, T., Nakamura, T., Nakamura, M., Sotozono, C., Masui, S., & Kinoshita, S. (2019). Direct reprogramming into corneal epithelial cells using a transcriptional network comprising PAX6, OVOL2, and KLF4. Cornea, 38, S34-S41.

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For research use only. Not intended for any clinical use.

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