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Mouse Anti-OTUB2 Recombinant Antibody (CBXO-0207) (CBMAB-O0716-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0207
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Immunogen
Full length human Recombinant protein of human OTUB2 (NP_075601) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, containing 1% BSA, 50% glycerol
Preservative
0.02% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
OTUB2
Introduction
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.
Entrez Gene ID
78990
UniProt ID
Q96DC9
Alternative Names
OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2; OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 2; Ubiquitin-Specific-Processing Protease OTUB2; OTU Domain, Ubiquitin Aldehyde Binding 2; Deubiquitinating Enzyme OTUB2; Otubain-2; C14orf137
Function
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Biological Process
Negative regulation of double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone H2A K63-linked ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Protein deubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein K11-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K48-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
More Infomation

Ren, W., Xu, Z., Chang, Y., Ju, F., Wu, H., Liang, Z., ... & Xia, N. (2024). Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Nature Communications, 15(1), 9.

Xiao, J., Wang, L., Zhuang, Y., Zhu, Q., Li, W., Liao, H., ... & Liu, Z. (2024). The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1. American Journal of Translational Research, 16(1), 75.

Zhang, Q., Zhang, J., Yao, A., Tian, X., Han, Z., Yuan, Y., ... & Yang, X. (2023). OTUB2 promotes the progression of endometrial cancer by regulating the PKM2‐mediated PI3K/AKT signaling pathway. Cell Biology International, 47(2), 428-438.

Ouyang, S., Zeng, Z., Liu, Z., Zhang, Z., Sun, J., Wang, X., ... & Kang, W. (2022). OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer. Cell Death Discovery, 8(1), 45.

Yu, S., Zang, W., Qiu, Y., Liao, L., & Zheng, X. (2022). Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis. Oncogene, 41(1), 46-56.

Hu, G., Yang, J., Zhang, H., Huang, Z., & Yang, H. (2022). OTUB2 promotes proliferation and migration of hepatocellular carcinoma cells by PJA1 deubiquitylation. Cellular and Molecular Bioengineering, 15(3), 281-292.

Sivakumar, D., Kumar, V., Naumann, M., & Stein, M. (2020). Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases. Journal of Biological Chemistry, 295(20), 6972-6982.

Li, J., Cheng, D., Zhu, M., Yu, H., Pan, Z., Liu, L., ... & Yao, M. (2019). OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics, 9(1), 179.

Zhang, Z., Du, J., Wang, S., Shao, L., Jin, K., Li, F., ... & Zhang, L. (2019). OTUB2 promotes cancer metastasis via hippo-independent activation of YAP and TAZ. Molecular cell, 73(1), 7-21.

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For research use only. Not intended for any clinical use.

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