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Mouse Anti-OSBPL8 Recombinant Antibody (CBXO-0489) (CBMAB-O0596-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0489
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.7 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
oxysterol binding protein-like 8
Introduction
This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
114882
UniProt ID
Q9BZF1
Alternative Names
Oxysterol Binding Protein Like 8; OSBP-Related Protein 8; OSBP10; ORP8; Oxysterol-Binding Protein-Related Protein 8; Oxysterol Binding Protein-Like 8
Function
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935).
Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).
Biological Process
Activation of protein kinase B activityISS:BHF-UCL
Fat cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylserine acyl-chain remodelingTAS:Reactome
Phospholipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glucose importISS:BHF-UCL
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of protein kinase B signalingISS:BHF-UCL
Protein localization to nuclear poreIEA:Ensembl
Cellular Location
Isoform 1
Endoplasmic reticulum membrane
Nucleus membrane
The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable).
Isoform 3
Endoplasmic reticulum membrane
Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.
Topology
Helical: 871-888
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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