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Mouse Anti-ORAI3 Recombinant Antibody (CBXO-0071) (CBMAB-O0523-CQ)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXO-0071
Antibody Isotype
IgG2a
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3
Specificity
Rat
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ORAI Calcium Release-Activated Calcium Modulator 3
Introduction
ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI2.
Entrez Gene ID
309000
UniProt ID
Q6AXR8
Alternative Names
ORAI Calcium Release-Activated Calcium Modulator 3; Transmembrane Protein 142C; TMEM142C; Protein Orai-3
Function
Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.
Biological Process
Store-operated calcium entryManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
More Infomation

Tiffner, A., Maltan, L., Fahrner, M., Sallinger, M., Weiß, S., Grabmayr, H., ... & Derler, I. (2021). Transmembrane domain 3 (TM3) governs orai1 and orai3 pore opening in an isoform-specific manner. Frontiers in Cell and Developmental Biology, 9, 635705.

Arora, S., Tanwar, J., Sharma, N., Saurav, S., & Motiani, R. K. (2021). Orai3 regulates pancreatic cancer metastasis by encoding a functional store operated calcium entry channel. Cancers, 13(23), 5937.

Gammons, J., Trebak, M., & Mancarella, S. (2021). Cardiac‐Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice. Journal of the American Heart Association, 10(8), e019486.

Chamlali, M., Kouba, S., Rodat-Despoix, L., Todesca, L. M., Pethö, Z., Schwab, A., & Ouadid-Ahidouch, H. (2021). Orai3 calcium channel regulates breast cancer cell migration through calcium-dependent and-independent mechanisms. Cells, 10(12), 3487.

Dubois, C., Kondratska, K., Kondratskyi, A., Morabito, A., Mesilmany, L., Farfariello, V., ... & Prevarskaya, N. (2021). ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(7), 119023.

Sanchez-Collado, J., Jardin, I., López, J. J., Ronco, V., Salido, G. M., Dubois, C., ... & Rosado, J. A. (2021). Role of Orai3 in the Pathophysiology of Cancer. International Journal of Molecular Sciences, 22(21), 11426.

Zhang, X., Xin, P., Yoast, R. E., Emrich, S. M., Johnson, M. T., Pathak, T., ... & Trebak, M. (2020). Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. Cell calcium, 91, 102281.

Tanwar, J., Arora, S., & Motiani, R. K. (2020). Orai3: Oncochannel with therapeutic potential. Cell Calcium, 90, 102247.

Azimi, I., Milevskiy, M. J., Chalmers, S. B., Yapa, K. T., Robitaille, M., Henry, C., ... & Monteith, G. R. (2019). ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses. Cancers, 11(2), 208.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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