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Mouse Anti-OGFOD1 Recombinant Antibody (1F4) (CBMAB-O0325-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG1
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium Azide
Concentration
0.41 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1
Introduction
OGFOD1 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
Entrez Gene ID
55239
UniProt ID
Q8N543
Alternative Names
2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1; 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 1; Termination And Polyadenylation 1 Homolog; US12 Prolyl 3-Hydroxylase; TPA1; TPA1, Termination And Polyadenylation 1, Homolog (S. Cerevisiae); 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1
Function
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-proline hydroxylationManual Assertion Based On ExperimentIDA:CACAO
Protein hydroxylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translational terminationManual Assertion Based On ExperimentIMP:UniProtKB
Stress granule assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.
Isoform 2
Cytoplasm
More Infomation

Xie, J., Zhang, Y., Li, B., Xi, W., Wang, Y., Li, L., ... & Zhang, Z. (2024). Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke. Journal of Translational Medicine, 22(1), 1-27.

Fujisaki, T., Saito, K., Kikuchi, T., & Kondo, E. (2023). The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators. FEBS letters, 597(8), 1073-1085.

Rodriguez, R., Harris, M., Murphy, E., & Kennedy, L. M. (2023). OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility. Journal of Molecular and Cellular Cardiology, 179, 42-46.

Harris, M., Sun, J., Keeran, K., Aponte, A., Singh, K., Springer, D., ... & Kennedy, L. M. (2022). Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia–reperfusion injury. Cardiovascular Research, 118(13), 2847-2858.

Lee, H. T., Lee, I. H., Kim, J. H., Lee, S., Kwak, S., Suh, M. Y., ... & Youn, H. D. (2021). Phosphorylation of OGFOD1 by cell cycle-dependent kinase 7/9 enhances the transcriptional activity of RNA polymerase II in breast cancer cells. Cancers, 13(14), 3418.

Kennedy, L., Sun, J., Harris, M., Cockman, M., Ratcliffe, P., & Murphy, E. (2020). Abstract MP121: Deleting the 2-oxoglutarate-and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective. Circulation Research, 127(Suppl_1), AMP121-AMP121.

Yin, D., Wang, Q., Wang, S., Zhu, G., Tang, Q., & Liu, J. (2020). OGFOD1 negatively regulated by miR-1224-5p promotes proliferation in human papillomavirus-infected laryngeal papillomas. Molecular Genetics and Genomics, 295, 675-684.

Harris, M., Kennedy, L., Sun, J., Cockman, M., Ratcliffe, P., & Murphy, E. (2020). Endoplasmic Reticulum Stress Alters the Localization of the Prolyl Hydroxylase Ogfod1 in Adult Mouse Cardiomyocytes. Circulation Research, 127(Suppl_1), A317-A317.

Thinnes, C. C., Lohans, C. T., Abboud, M. I., Yeh, T. L., Tumber, A., Nowak, R. P., ... & Schofield, C. J. (2019). Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry–A European Journal, 25(8), 2019-2024.

Stoehr, A., Kennedy, L., Yang, Y., Patel, S., Lin, Y., Linask, K. L., ... & Murphy, E. (2019). The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing. JCI insight, 4(13).

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For research use only. Not intended for any clinical use.

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