Mouse Anti-NXNL1 Recombinant Antibody (7H3) (CBMAB-N4063-WJ)

Name: Mouse Anti-NXNL1 Recombinant Antibody (7H3)
SKU: CBMAB-N4063-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

7H3

Antibody Isotype

IgG2b, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nucleoredoxin-like 1

Introduction

Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015]

Entrez Gene ID

115861

UniProt ID

Q96CM4

Alternative Names

Nucleoredoxin Like 1; Rod-Derived Cone Viability Factor; Thioredoxin-Like Protein 6; Thioredoxin-Like 6; TXNL6; Nucleoredoxin-Like Protein 1; RDCVF;

Function

Plays an important role in retinal cone photoreceptor survival (PubMed:25957687).
In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity).

Biological Process

Photoreceptor cell maintenanceManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell projection, cilium, photoreceptor outer segment

More Infomation

References

Kim, K. M., & Jang, W. G. (2022). NXNL1 negatively regulates osteoblast differentiation via GDF15‐induced PP2A Cα dependent manner in MC3T3‐E1 cells. BioFactors, 48(1), 239-248.

Gao, H., & Lv, L. (2022). Increased expression of NXNL1 in breast cancer associated with favorable prognostic and high level of immune infiltration.

Ait-Ali, N., Blond, F., Lee, S., Wang, S., Cobrinik, D., & Leveillard, T. D. (2019). NCL is implicated in the NXNL1 gene splicing and leads to RdCVF expression in retinoblastoma cell lines. Investigative Ophthalmology & Visual Science, 60(9), 4940-4940.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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