Rabbit Anti-NUDT2 Recombinant Antibody (CBWJN-1601) (CBMAB-N3892-WJ)

Name: Rabbit Anti-NUDT2 Recombinant Antibody (CBWJN-1601)
SKU: CBMAB-N3892-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBWJN-1601

Antibody Isotype

IgG

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 2

Introduction

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Entrez Gene ID

318

UniProt ID

P50583

Alternative Names

Nudix Hydrolase 2; Diadenosine Tetraphosphatase; Ap4Aase; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 2; Diadenosine 5,5-P1,P4-Tetraphosphate Asymmetrical Hydrolase; Diadenosine 5,5-P1,P4-Tetraphosphate Pyrophosphohydrolase; Bis(5-Nucleosyl)-Tetraphosphatase (Asymmetrical); Nucleoside Diphosphate-Linked Moiety X Motif 2;

Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity).
Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).

Biological Process

AMP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Apoptotic processBy SimilarityISS:UniProtKB
ATP biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressTAS:Reactome
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrial matrix

More Infomation

References

Bi, B., Chen, X., Huang, S., Peng, M., Gu, W., Zhu, H., & Ming, Y. (2024). The first case of intellectual disability caused by novel compound heterozygosity for NUDT2 variants. BMC pediatrics, 24(1), 60.

Hidmi, S., Nechushtan, H., Razin, E., & Tshori, S. (2023). Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma. International Journal of Molecular Sciences, 24(13), 10513.

Husain, R. A., Jiao, X., Hennings, J. C., Giesecke, J., Palsule, G., Beck-Wödl, S., ... & Rubio, I. (2023). Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease. Brain, awad434.

Razin, E., Abu-rahmah, R., Nechushtan, H., Meirovitz, A., & Peretz, T. (2023). The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer.

Laudenbach, B. T., Krey, K., Emslander, Q., Andersen, L. L., Reim, A., Scaturro, P., ... & Pichlmair, A. (2021). NUDT2 initiates viral RNA degradation by removal of 5′-phosphates. Nature Communications, 12(1), 6918.

Mishra, S., Khosa, S., Lee, H., Singer, R., Diaz, F., Freundlich, R., ... & Fogel, B. L. (2020). NUDT2 Associated Syndrome with Developmental Delay and Peripheral Neuropathy.(1629).

Diaz, F., Khosa, S., Niyazov, D., Lee, H., Person, R., Morrow, M. M., ... & Mishra, S. K. (2020). Novel NUDT2 variant causes intellectual disability and polyneuropathy. Annals of Clinical and Translational Neurology, 7(11), 2320-2325.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-NUDT2 Recombinant Antibody (4A4-3C3)

Mouse Anti-NUDT2 Recombinant Antibody (CBWJN-0406)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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